Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer

被引：30

作者：

Jain, Vikram K. ^{[3
]}

Turner, Nicholas C. ^{[1
,2
]}

机构：

[1] Royal Marsden Hosp, Breast Unit, London SW3 6JJ, England

[2] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

[3] Royal Marsden Hosp, GI Unit, Sutton SM2 5PT, Surrey, England

来源：

BREAST CANCER RESEARCH | 2012年 / 14卷 / 03期

关键词：

FGFR4 GLY388ARG POLYMORPHISM; GENOME-WIDE ASSOCIATION; THERAPEUTIC TARGET; MULTIPLE-MYELOMA; MOUSE MODEL; CELL-LINES; EXPRESSION; AMPLIFICATION; CARCINOMA; ANTIBODY;

D O I：

10.1186/bcr3139

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activation of the fibroblast growth factor receptor pathway is a common event in many cancer types. Here we review the role of fibroblast growth factor receptor signalling in breast cancer, from SNPs in FGFR2 that influence breast cancer risk and SNPs in FGFR4 that associate with breast cancer prognosis, and potential therapeutic targets such as receptor amplification and aberrant autocrine and paracrine ligand expression. We discuss the multiple therapeutic strategies in preclinical and clinical development and the current and future challenges to successfully targeting this pathway in cancer.

引用

页数：9

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