Can procalcitonin differentiate Staphylococcus aureus from coagulase-negative staphylococci in clustered gram-positive bacteremia?

被引：19

作者：

Shomali, William ^{[1
]}

Hachem, Ray ^{[1
]}

Chaftari, Anne-Marie ^{[1
]}

Bahu, Ramez ^{[1
]}

El Helou, Gilbert ^{[1
]}

Jiang, Ying ^{[1
]}

Hanania, Alex ^{[1
]}

Reitzel, Ruth ^{[1
]}

Raad, Issam ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2013年 / 76卷 / 02期

关键词：

Staphylococcus; Bacteremia; Biomarker; Procalcitonin; CoNS; BLOOD-STREAM INFECTION; SERUM PROCALCITONIN; RISK-FACTORS; SEPSIS; MANAGEMENT; DIAGNOSIS; ADRENOMEDULLIN; CONTAMINATION; MARKER;

D O I：

10.1016/j.diagmicrobio.2013.03.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Procalcitonin (PCT) and pro-adrenomedullin (ProADM) have been proposed as diagnostic and prognostic biomarkers of infection. Between July 2009 and January 2012, we studied the role of these biomarkers in 163 patients with clustered gram-positive and gram-negative bacteremia. PCT levels were significantly higher in patients with Staphylococcus aureus and gram-negative bacteremia than those with coagulase-negative staphylococci (CONS) isolated from blood cultures (P = 0.29 and <0.001, respectively). ProADM levels were only significantly higher in patients with gram-negative bacteremia (median 1.46 nmol/L) than those with CoNS (median 1.01 nmol/L) (P = 0.04). Among patients with CoNS, PCT, and ProADM, levels failed to differentiate blood contamination (medians 0.24 ng/mL and 0.97 nmol/L) from true bacteremia (medians 0.26 ng/mL and 1.14 nmol/L) (P = 0.51 and 0.57, respectively). In cancer patients, PCT (and to a lesser extent, ProADM) was useful in differentiating CoNS from S. aureus and gram-negative bacteremia. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：158 / 161

页数：4

共 22 条

[1] HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION [J].