Microautophagy in the visceral endoderm is essential for mouse early development

被引：12

作者：

Wada, Yoh ^{[1
]}

Sun-Wada, Ge-Hong ^{[2
]}

Kawamura, Nobuyuki ^{[2
]}

机构：

[1] Osaka Univ, Div Biol Sci, Inst Sci & Ind Res, Osaka, Japan

[2] Doshisha Womans Coll, Fac Pharmaceut Sci, Kyoto, Japan

来源：

AUTOPHAGY | 2013年 / 9卷 / 02期

关键词：

autophagy; apical vacuole; microautophagy; RAB7; early mouse evelopment;

D O I：

10.4161/auto.22585

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During early embryogenesis, before the conceptus forms the placenta, maternal nutrients as well as signaling molecules must reach the embryo proper through a tightly sealed epithelial tissue, the visceral endoderm (VE). The VE serves as a signaling center for embryogenesis, where exocytic and endocytic processes integrate signal production, perception and termination. However, the endocytic process in this important tissue has not been well characterized. We show that endocytic delivery to the lysosomes occurs via RAB7-dependent microautophagy. This process is essential for early mammalian development.

引用

页码：252 / 254

页数：3