OCCURRENCE OF KILLER CANDIDA GLABRATA CLINICAL ISOLATES

被引：0

作者：

Arroyo-Helguera, O. ^{[1
]}

De Las Penas, Alejandro ^{[2
]}

Castano, Irene ^{[2
]}

机构：

[1] Univ Veracruzana, Inst Salud Publ, Xalapa 91190, Veracruz, Mexico

[2] Inst Potosino Invest Cient & Tecnol, Div Mol Biol, San Luis Potosi 78216, Mexico

来源：

BRAZILIAN JOURNAL OF MICROBIOLOGY | 2012年 / 43卷 / 03期

关键词：

Candida glabrata; killer activity; yeast; Saccharomyces; PROGRAMMED CELL-DEATH; DOUBLE-STRANDED-RNA; SACCHAROMYCES-CEREVISIAE; ANTIFUNGAL AGENTS; YEAST; APOPTOSIS; SUSCEPTIBILITY; EPIDEMIOLOGY; SURVEILLANCE; MICAFUNGIN;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this work we characterized the occurrence of killer activity in 64 Candida glabrata clinical isolates under different conditions. We found that only 6.25 % of the clinical isolates tested were positive for killer activity against a Saccharomyces cerevisiae W303 sensitive strain. Sensitivity of killer activity to different values of pH and temperatures was analyzed. We found that the killer activity presented by all isolates was resistant to every pH and temperature tested, although optimal activity was found at a range of pH values from 4 to 7 and at 37 degrees C. We did not observe extrachromosomal genetic elements associated with killer activity in any of the positive C. glabrata isolates. The killer effect was due to a decrease in viability and DNA fragmentation in sensitive yeast.

引用

页码：880 / 887

页数：8

共 29 条

[1] THE KILLER PHENOMENON IN YEASTS [J].

BENDOVA, O .

FOLIA MICROBIOLOGICA, 1986, 31 (05) :422-433

[2]

Cormack BP, 1999, GENETICS, V151, P979

[3] Induction of apoptosis in yeast and mammalian cells by exposure to 1,10-phenanthroline metal complexes [J].

Coyle, B ;

Kinsella, P ;

McCann, M ;

Devereux, M ;

O'Connor, R ;

Clynes, M ;

Kavanagh, K .

TOXICOLOGY IN VITRO, 2004, 18 (01) :63-70

[4] Cell cycle and morphological alterations as indicative of apoptosis promoted by UV irradiation in S-cerevisiae [J].

Del Carratore, R ;

Della Croce, C ;

Simili, M ;

Taccini, E ;

Scavuzzo, M ;

Sbrana, S .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2002, 513 (1-2) :183-191

[5] Candida glabrata:: Review of epidemiology, pathogenesis, and clinical disease with comparison to C-albicans [J].

Fidel, PL ;

Vazquez, JA ;

Sobel, JD .

CLINICAL MICROBIOLOGY REVIEWS, 1999, 12 (01) :80-+

[6] Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents:: Results of a 3-year (2004 to 2007) surveillance study [J].

Gonzalez, Gloria M. ;

Elizondo, Mariana ;

Ayala, Jacobo .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (09) :2902-2905

[7] UV HYPERSENSITIVITY OF YEAST LINEAR PLASMIDS [J].

GUNGE, N ;

TAKAHASHI, S ;

FUKUDA, K ;

OHNISHI, T ;

MEINHARDT, F .

CURRENT GENETICS, 1994, 26 (04) :369-373

[8] Chronological aging leads to apoptosis in yeast [J].

Herker, E ;

Jungwirth, H ;

Lehmann, KA ;

Maldener, C ;

Fröhlich, KU ;

Wissing, S ;

Büttner, S ;

Fehr, M ;

Sigrist, S ;

Madeo, F .

JOURNAL OF CELL BIOLOGY, 2004, 164 (04) :501-507

[9] KILLER PHENOMENON IN PATHOGENIC YEAST [J].

KANDEL, JS ;

STERN, TA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 15 (04) :568-571

[10] Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis [J].

Laun, P ;

Pichova, A ;

Madeo, F ;

Fuchs, J ;

Ellinger, A ;

Kohlwein, S ;

Dawes, I ;

Fröhlich, KU ;

Breitenbach, M .

MOLECULAR MICROBIOLOGY, 2001, 39 (05) :1166-1173

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