Beyond the RNA-dependent function of LncRNA genes

被引：242

作者：

Ali, Tamer ^{[1
,2
]}

Grote, Phillip ^{[1
]}

机构：

[1] Goethe Univ, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany

[2] Benha Univ, Fac Sci, Banha, Egypt

来源：

ELIFE | 2020年 / 9卷

关键词：

LONG NONCODING RNAS; XIST GENE; TRANSCRIPTION; EXPRESSION; ACTIVATION; DOMAINS; MOUSE; TERMINATION; REPEATS; PRODUCT;

D O I：

10.7554/eLife.60583

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the last decade, the focus regarding their mechanisms of action has been primarily on the RNA product of these genes. Recent work on several lncRNAs genes demonstrates that not only is the produced RNA species important, but also that transcription of the lncRNA locus alone can have regulatory functions. Like the functions of lncRNA transcripts, the mechanisms that underlie these genome-based functions are varied. Here we highlight some of these examples and provide an outlook on how the functional mechanisms of a lncRNA gene can be determined.

引用

页码：1 / 14

页数：14

共 70 条

[1] MYC ONCOGENE ACTIVATION IN B-LYMPHOID AND T-LYMPHOID TUMORS [J].

ADAMS, JM ;

CORY, S .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1985, 226 (1242) :59-72

[2] Insulators and domains of gene expression [J].

Ali, Tamer ;

Renkawitz, Rainer ;

Bartkuhn, Marek .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2016, 37 :17-26

[3] Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development [J].

Anderson, Kelly M. ;

Anderson, Douglas M. ;

McAnally, John R. ;

Shelton, John M. ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

NATURE, 2016, 539 (7629) :433-436

[4] Deficiency in the nuclear long noncoding RNA Charme causes myogenic defects and heart remodeling in mice [J].

Ballarino, Monica ;

Cipriano, Andrea ;

Tita, Rossella ;

Santini, Tiziana ;

Desideri, Fabio ;

Morlando, Mariangela ;

Colantoni, Alessio ;

Carrieri, Claudia ;

Nicoletti, Carmine ;

Musaro, Antonio ;

O'Carroll, Donal ;

Bozzoni, Irene .

EMBO JOURNAL, 2018, 37 (18)

[5] A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus [J].

Barutcu, A. Rasim ;

Maass, Philipp G. ;

Lewandowski, Jordan P. ;

Weiner, Catherine L. ;

Rinn, John L. .

NATURE COMMUNICATIONS, 2018, 9

[6] Conserved noncoding transcription and core promoter regulatory code in early Drosophila development [J].

Batut, Philippe J. ;

Gingeras, Thomas R. .

ELIFE, 2017, 6

[7] Ten things you should know about transposable elements [J].

Bourque, Guillaume ;

Burns, Kathleen H. ;

Gehring, Mary ;

Gorbunova, Vera ;

Seluanov, Andrei ;

Hammell, Molly ;

Imbeault, Michael ;

Izsvak, Zsuzsanna ;

Levin, Henry L. ;

Macfarlan, Todd S. ;

Mager, Dixie L. ;

Feschotte, Cedric .

GENOME BIOLOGY, 2018, 19

[8] THE PRODUCT OF THE H19 GENE MAY FUNCTION AS AN RNA [J].

BRANNAN, CI ;

DEES, EC ;

INGRAM, RS ;

TILGHMAN, SM .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (01) :28-36

[9] THE PRODUCT OF THE MOUSE XIST GENE IS A 15 KB INACTIVE X-SPECIFIC TRANSCRIPT CONTAINING NO CONSERVED ORF AND LOCATED IN THE NUCLEUS [J].

BROCKDORFF, N ;

ASHWORTH, A ;

KAY, GF ;

MCCABE, VM ;

NORRIS, DP ;

COOPER, PJ ;

SWIFT, S ;

RASTAN, S .

CELL, 1992, 71 (03) :515-526

[10] THE HUMAN XIST GENE - ANALYSIS OF A 17 KB INACTIVE X-SPECIFIC RNA THAT CONTAINS CONSERVED REPEATS AND IS HIGHLY LOCALIZED WITHIN THE NUCLEUS [J].

BROWN, CJ ;

HENDRICH, BD ;

RUPERT, JL ;

LAFRENIERE, RG ;

XING, Y ;

LAWRENCE, J ;

WILLARD, HF .

CELL, 1992, 71 (03) :527-542

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