Optimization of chronic stress paradigms using anxiety- and depression-like behavioral parameters

被引:173
作者
Kim, KS
Han, PL
机构
[1] Ewha Womans Univ, Sch Med, Dept Neurosci, Seoul 158710, South Korea
[2] Ewha Womans Univ, Sch Med, Inst Med Res, Seoul, South Korea
关键词
chronic restraint stress; anxiety; depression; microarray;
D O I
10.1002/jnr.20754
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chronic stress is a risk factor for psychiatric illnesses, such as anxiety and depression disorders. To understand the underlying mechanism regarding how chronic stress triggers such psychiatric dysfunctions, restraint-based chronic stress models have been attempted in the past. However, total durations of repeated restraint stress and the evaluation time points used after the last restraint application vary from experiment to experiment. One reason for these methodological heterogeneities is related to considerable ambiguity concerning the definition of chronic stress, particularly in animal models. In the present study, we used behavioral traits, anxiety and depression, as stress-assessment parameters that meet operationally useful requirements for the definition of the chronic stress state. We demonstrate that restraint treatment for 2 or 8 hr daily for 14 days is enough to produce anxiety- and depression-like behaviors, whereas a 2 hr-10 days restraint was marginally effective. cDNA microarray analysis identified 34 genes in the hippocampus and 72 genes in the amygdala with expression levels that were up- or down-regulated by > 2.0-fold. Among the wide range of genes identified in this analysis, genes required for energy metabolism, signal transduction, transcription, synaptic plasticity, and remodeling of the brain architecture were notable. Our results suggest that the psychiatric criteria of anxiety and depression can be used as chronic stress-assessment parameters and that a restraint stress paradigm consisting of restraint treatment for 2 or 8 hr daily for 14 days could be used as a prototype paradigm for chronic stress studies. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码:497 / 507
页数:11
相关论文
共 53 条
[1]   The effect of chronic restraint stress on spatial learning and memory:: Relation to oxidant stress [J].
Abidin, I ;
Yargiçoglu, P ;
Agar, A ;
Gümüslu, S ;
Aydin, S ;
Öztürk, O ;
Sahin, E .
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2004, 114 (05) :683-699
[2]   LASTING EFFECTS ON RODENT ANXIETY OF A SINGLE EXPOSURE TO A CAT [J].
ADAMEC, RE ;
SHALLOW, T .
PHYSIOLOGY & BEHAVIOR, 1993, 54 (01) :101-109
[3]   Neural plasticity and stress induced changes in defense in the rat [J].
Adamec, RE ;
Blundell, J ;
Collins, A .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2001, 25 (7-8) :721-744
[4]   PSYCHONEUROIMMUNOLOGY - CONDITIONING AND STRESS [J].
ADER, R ;
COHEN, N .
ANNUAL REVIEW OF PSYCHOLOGY, 1993, 44 :53-85
[5]   FORCED SWIMMING TEST IN RATS - EFFECT OF DESIPRAMINE ADMINISTRATION AND THE PERIOD OF EXPOSURE TO THE TEST ON STRUGGLING BEHAVIOR, SWIMMING, IMMOBILITY AND DEFECATION RATE [J].
ARMARIO, A ;
GAVALDA, A ;
MARTI, O .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 158 (03) :207-212
[6]   INFLUENCE OF VARIOUS ACUTE STRESSORS ON THE ACTIVITY OF ADULT MALE-RATS IN A HOLEBOARD AND IN THE FORCED SWIM TEST [J].
ARMARIO, A ;
GIL, M ;
MARTI, J ;
POL, O ;
BALASCH, J .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 39 (02) :373-377
[7]   Chronic psychosocial stress-induced down-regulation of immunity depends upon individual factors [J].
Bartolomucci, A ;
Sacerdote, P ;
Panerai, AE ;
Peterzani, T ;
Palanza, P ;
Parmigiani, S .
JOURNAL OF NEUROIMMUNOLOGY, 2003, 141 (1-2) :58-64
[8]   Molecular mechanism of growth hormone action [J].
CarterSu, C ;
Schwartz, J ;
Smit, LS .
ANNUAL REVIEW OF PHYSIOLOGY, 1996, 58 :187-207
[9]   The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes [J].
Chrousos, GP .
INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (Suppl 2) :S50-S55
[10]   Chronic stress alters dendritic morphology in rat medial prefrontal cortex [J].
Cook, SC ;
Wellman, CL .
JOURNAL OF NEUROBIOLOGY, 2004, 60 (02) :236-248