5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

被引：43
作者：
Valdes, Pablo A. [1 ]
Millesi, Matthias [2 ]
Widhalm, Georg [2 ]
Roberts, David W. [3 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurosurg, 60 Fenwood Rd, Boston, MA 02115 USA
[2] Med Univ Vienna, Dept Neurosurg, Wahringer Gurtel 18-20, Vienna, Austria
[3] Dartmouth Hitchcock Med Ctr, Dept Neurosurg, 1 Med Ctr Dr, Lebanon, NH 03766 USA
来源：
JOURNAL OF NEURO-ONCOLOGY | 2019年 / 141卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Fluorescence-guided surgery; 5-Aminolevulinic acid; Protoporphyrin IX; Quantitative fluorescence; Meningioma; Spectroscopy; GUIDED RESECTION; INTRACRANIAL MENINGIOMAS; MALIGNANT GLIOMAS; RECURRENCE; INFILTRATION; EXPERIENCE; IMPACT; EXTENT;
D O I：
10.1007/s11060-018-03079-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors.MethodsHere we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas.ResultsWe discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas.ConclusionsThe use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.
引用
收藏
页码：555 / 565
页数：11
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