Reversible myelopathy on magnetic resonance imaging due to cobalamin deficiency

被引：21

作者：

Lee, Wei-Ju ^{[1
]}

Hsu, Hung-Yi ^{[1
,2
]}

Wang, Pao-Yu ^{[1
,2
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Med, Div Neurol, Taichung 407, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

来源：

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION | 2008年 / 71卷 / 07期

关键词：

magnetic resonance imaging; myelopathy; subacute combined degeneration; vitamin B12 deficiency;

D O I：

10.1016/S1726-4901(08)70142-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Subacute combined degeneration (SCD) is known as myelopathy due to vitamin B12 deficiency. SCD always involves the posterior and lateral columns of the spinal cord, with the neuropathologic change showing vacuolation of the white matter. We describe 2 patients who presented with ataxic gait, impaired proprioception over limbs, and even mental change due to vitamin B12 deficiency. Magnetic resonance imaging (MRI) of the cervical spine showed increased signal intensity on T2-weighted imaging, and laboratory data showed low serum vitamin B12 level. The 2 patients were treated with vitamin B12 injection intramuscularly. There was clinical improvement: after treatment along with normalization of the MRI.

引用

页码：368 / 372

页数：5

共 11 条

[1] Spinal MRI precedes clinical improvement in subacute combined degeneration with B12 deficiency [J].

Berlit, P ;

Ringelstein, A ;

Liebig, T .

NEUROLOGY, 2004, 63 (03) :592-592

[2] Spinal MRI supporting myelopathic origin of early symptoms in unsuspected cobalamin deficiency [J].

Fritschi, J ;

Sturzenegger, M .

EUROPEAN NEUROLOGY, 2003, 49 (03) :146-150

[3]

FU CH, 2004, TZU CHI MED J, V16, P199

[4] Subacute combined degeneration of the spinal cord with involvement of the anterior columns: a new MRI finding [J].

Karantanas, AH ;

Markonis, A ;

Bisbiyiannis, G .

NEURORADIOLOGY, 2000, 42 (02) :115-117

[5] MRI of spinal cord and brain lesions in subacute combined degeneration [J].

Katsaros, VK ;

Glocker, FX ;

Hemmer, B ;

Schumacher, M .

NEURORADIOLOGY, 1998, 40 (11) :716-719

[6] MRI appearances in subacute combined degeneration of the spinal cord due to vitamin B12 deficiency [J].

Larner, AJ ;

Zeman, AZJ ;

Allen, CMC ;

Antoun, NM .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (01) :99-100

[7] Reversible myelopathy in a 34-year-old man with vitamin B12 deficiency [J].

Pittock, SJ ;

Payne, TA ;

Harper, CM .

MAYO CLINIC PROCEEDINGS, 2002, 77 (03) :291-294

[8]

Samuels MA, 2003, PRACT NEUROL, V3, P132

[9] Cobalamin (vitamin B12) in subacute combined degeneration and beyond:: traditional interpretations and novel theories [J].

Scalabrino, G .

EXPERIMENTAL NEUROLOGY, 2005, 192 (02) :463-479

[10] High tumor necrosis factor-α in levels in cerebrospinal fluid of cobalamin-deficient patients [J].

Scalabrino, G ;

Carpo, M ;

Bamonti, F ;

Pizzinelli, S ;

D'Avino, C ;

Bresolin, N ;

Meucci, G ;

Martinelli, V ;

Comi, GC ;

Peracchi, M .

ANNALS OF NEUROLOGY, 2004, 56 (06) :886-890

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