Occult Hepatitis B Virus Infection in Patients With Chronic Hepatitis C Treated With Antiviral Therapy

被引:14
作者
Caviglia, Gian Paolo [1 ]
Abate, Maria Lorena [1 ]
Manzini, Paola [2 ]
Danielle, Franca [2 ]
Ciancio, Alessia
Rosso, Chiara [1 ]
Olivero, Antonella [1 ]
Pellicano, Rinaldo
Touscoz, Giovanni Antonio [3 ]
Smedile, Antonina [3 ]
Rizzetto, Mario [3 ]
机构
[1] Univ Turin, Dept Internal Med, Turin, Italy
[2] San Giovanni Battista Univ Hosp Molinette, Blood Bank, Turin, Italy
[3] San Giovanni Battista Univ Hosp Molinette, Dept Gastroenterol & Hepatol, I-10100 Turin, Italy
关键词
Hepatitis C; Chronic; Hepatitis B Virus; Infection; SURFACE-ANTIGEN; PEGYLATED INTERFERON; LIVER-DISEASE; HBV INFECTION; PREVALENCE; RIBAVIRIN; IMPACT; ANTIBODY; GENE;
D O I
10.5812/hepatmon.7292
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the liver and/or in the serum of patients with negative results of hepatitis B s antigen (HBsAg) test with or without serological markers of previous viral exposure. The impact of OBI in patients with chronic hepatitis C (CHC) is still unclear. Objectives: The Aim of this study was to assess OBI prevalence and its potential implications on treatment outcome in a cohort of patients with CHC underwent standard antiviral therapy. Patients and Methods: Baseline serum samples from 137 HBsAg-negative CHC patients treated with pegylated-interferon and ribavirin (73 Responders/74 Non Responders), were retrospectively analyzed for HBV status. Results: Seventy-three patients (53.3%) showed markers of previous exposure to HBV. HBV DNA was detected in 2 of 137 serum samples (1.5%), both carrying HBV antibodies. Liver biopsies and post-therapy sera were available for 35 patients (12 Responders/23 Non Responders). HBV DNA sequences were found in 13 of 35 specimens (37.1%), all of patients with HBV DNA negativity in basal and post-therapy serum samples. Among OBI-positive patients, 5 (38.5%) carried serological markers of HBV infection. Regarding therapy outcome, in the OBI-positive group there were 5 of 13 (38.5%) sustained virological responders (SVR) compared to 7 of 22 (31.8%) in the OBI-negative one. Conclusions: Despite the high prevalence rate of liver HBV DNA in patients with CHC, SVR was not affected by occult HBV infection. Published by Kowsar Corp, 2012. cc 3.0.
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页数:5
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