The promises and challenges of human brain organoids as models of neuropsychiatric disease

被引：217

作者：

Quadrato, Giorgia ^{[1
]}

Brown, Juliana ^{[1
]}

Arlotta, Paola ^{[1
]}

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

NATURE MEDICINE | 2016年 / 22卷 / 11期

基金：

美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; IPSC-DERIVED NEURONS; PSYCHIATRIC-DISORDERS; HUMAN ES; CEREBRAL ORGANOIDS; SELF-ORGANIZATION; GENETIC RISK; SCHIZOPHRENIA; DIFFERENTIATION; DYSREGULATION;

D O I：

10.1038/nm.4214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuropsychiatric disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ) and bipolar disorder (BPD) are of great societal and medical importance, but the complexity of these diseases and the challenges of modeling the development and function of the human brain have made these disorders difficult to study experimentally. The recent development of 3D brain organoids derived from human pluripotent stem cells offers a promising approach for investigating the phenotypic underpinnings of these highly polygenic disorders and for understanding the contribution of individual risk variants and complex genetic background to human pathology. Here we discuss the advantages, limitations and future applications of human brain organoids as in vitro models of neuropsychiatric disease.

引用

页码：1220 / 1228

页数：9

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