Palladium Catalyzed Regioselective C4-Arylation and Olefination of Indoles and Azaindoles

被引：70
作者：
Thrimurtulu, Neetipalli [1 ]
Dey, Arnab [1 ]
Singh, Anurag [1 ]
Pal, Kuntal [1 ]
Maiti, Debabrata [1 ]
Volla, Chandra M. R. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 06期
关键词：
C-H activation; Palladium; Transient directing group; Indoles; Regioselective; C-H ACTIVATION; TRANSIENT DIRECTING GROUP; DIRECT ARYLATION; FUNCTIONALIZATION; ALDEHYDES; BENZALDEHYDES; ALKENYLATION; FLUORENONES; SILYLATION; ALKYLATION;
D O I：
10.1002/adsc.201801378
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A convergent strategy for the synthesis of biologically relevant C4-substituted indole scaffolds was demonstrated using Pd(II)-catalyzed remote C-H functionalization of indoles and azaindoles. The reaction displays high regioselectivity for the C4-position of indole-3-carbaldehydes using glycine as an inexpensive transient directing group. Notable features of this transformation include the selective formation of six-membered palladacyle and excellent functional group tolerance.
引用
收藏
页码：1441 / 1446
页数：6
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