Location and cellular stages of natural killer cell development

被引:281
作者
Yu, Jianhua [1 ,2 ,3 ,4 ]
Freud, Aharon G. [2 ,3 ,4 ,5 ]
Caligiuri, Michael A. [1 ,2 ,3 ,4 ]
机构
[1] Ohio State Univ, Coll Med, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[3] Ohio State Univ, James Canc Hosp, Columbus, OH 43210 USA
[4] Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA
[5] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
关键词
INNATE LYMPHOID-CELLS; MATURE NK-CELLS; HUMAN T-CELLS; C-KIT LIGAND; BONE-MARROW; ADAPTIVE IMMUNITY; TRANSCRIPTIONAL CONTROL; MEDIATED CYTOTOXICITY; LINEAGE RELATIONSHIPS; INTERFERON-GAMMA;
D O I
10.1016/j.it.2013.07.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The identification of distinct tissue-specific natural killer (NK) cell populations that apparently mature from local precursor populations has brought new insight into the diversity and developmental regulation of this important lymphoid subset. NK cells provide a necessary link between the early (innate) and late (adaptive) immune responses to infection. Gaining a better understanding of the processes that govern NK cell development should allow us to harness better NK cell functions in multiple clinical settings, as well as to gain further insight into how these cells undergo malignant transformation. In this review, we summarize recent advances in understanding sites and cellular stages of NK cell development in humans and mice.
引用
收藏
页码:573 / 582
页数:10
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