Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties

被引：26
|
作者：
Kasaian, Jamal [1 ,3 ,4 ]
Iranshahy, Milad [1 ,3 ,4 ]
Masullo, Milena [2 ,5 ]
Piacente, Sonia [2 ,5 ]
Ebrahimi, Fatemeh [1 ,3 ,4 ]
Iranshahi, Mehrdad [1 ,3 ,4 ]
机构：
[1] Mashhad Univ Med Sci, Biotechnol Res Ctr & Sch Pharm, Mashhad, Iran
[2] Univ Studi Salerno, Dipartimento Scienze Farmaceutiche, Salerno, Italy
[3] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran
[4] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
[5] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Salerno, Italy
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 03期
基金：
美国国家科学基金会;
关键词：
Ferula; Apiaceae; cytotoxic; Alamar blue; dehydrooopodin; sesquiterpene lactones; COUMARINS;
D O I：
10.1080/10286020.2013.866099
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sesquiterpene lactones, namely feruhodin A (1) and feruhodin B (2), together with six known compounds, daucoeudesmanolactone (4), dehydrooopodin (5), oopodin (6), badkhysin (3), 7-demethylplastochromenol (7), and scoparone (8), were isolated from the roots of Ferula oopoda. The structures of these compounds were elucidated by 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Cytotoxic effects of these compounds were evaluated against two human cancer cell lines including MCF7and K562 using the Alamar blue assay. The results showed that dehydrooopodin (5) possessed significant cytotoxic effects with IC50 values of 15 and 5M against MCF7 and K562, respectively.
引用
收藏
页码：248 / 253
页数：6
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