Cutaneous adverse reactions to anti-PD-1 treatment-A systematic review

被引：32

作者：

Simonsen, Anne Birgitte ^{[1
]}

Kaae, Jeanette ^{[1
]}

Ellebaek, Eva ^{[2
]}

Svane, Inge Marie ^{[2
]}

Zachariae, Claus ^{[1
]}

机构：

[1] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Copenhagen, Denmark

[2] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Oncol, Copenhagen, Denmark

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2020年 / 83卷 / 05期

关键词：

anti-PD-1; cutaneous adverse reaction; dermatology; immunotherapy; oncology; IMMUNE CHECKPOINT BLOCKADE; STEVENS-JOHNSON SYNDROME; PROGRAMMED CELL DEATH-1; METASTATIC MELANOMA; NIVOLUMAB THERAPY; LICHEN-PLANUS; PEMBROLIZUMAB THERAPY; LUNG-CANCER; PSORIASIFORM ERUPTION; DRUG ERUPTION;

D O I：

10.1016/j.jaad.2020.04.058

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The use of the humanized monoclonal anti-programmed cell death 1 antibodies pembrolizumab and nivolumab as potent anticancer therapies is rapidly increasing. However, since their approval, numerous cases of cutaneous reactions have been reported. Cutaneous adverse reactions to these agents have yet to be fully characterized and range from nonspecific eruptions to recognizable skin manifestations, which may be localized and vary from mild to life threatening. This systematic review article provides an overview of the various adverse cutaneous reactions to pembrolizumab and nivolumab therapy and offers suggestions for their management.

引用

页码：1415 / 1424

页数：10

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