PAS Kinase: A Nutrient Sensing Regulator of Glucose Homeostasis

被引：19

作者：

DeMille, Desiree ^{[1
]}

Grose, Julianne H. ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Microbiol & Mol Biol, Provo, UT 84604 USA

来源：

IUBMB LIFE | 2013年 / 65卷 / 11期

关键词：

PAS kinase; diabetes; glucose metabolism; signal transduction; obesity; nutrient sensing; WHOLE-GENOME DUPLICATION; PROTEIN-KINASES; SERINE/THREONINE KINASE; GLYCOGEN-SYNTHASE; YEAST; DOMAIN; PHOSPHORYLATION; METABOLISM; GROWTH; TRANSLATION;

D O I：

10.1002/iub.1219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose availability and regulates glucose homeostasis in yeast, mice, and man. Despite this pivotal role, the molecular mechanisms of PAS kinase regulation and function are largely unknown. This review focuses on what is known about PAS kinase, including its conservation from yeast to man, identified substrates, associated phenotypes and role in metabolic disease. (c) 2013 IUBMB Life, 65(11):921-929, 2013

引用

页码：921 / 929

页数：9

共 50 条

[1] Structure and interactions of PAS kinase N-terminal PAS domain: Model for intramolecular kinase regulation [J].

Amezcua, CA ;

Harper, SM ;

Rutter, J ;

Gardner, KH .

STRUCTURE, 2002, 10 (10) :1349-1361

[2] Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic β-cells [J].

An, R. ;

da Silva Xavier, G. ;

Hao, H. -X. ;

Semplici, F. ;

Rutter, J. ;

Rutter, G. A. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 :791-793

[3] Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms [J].

Boucher, MJ ;

Selander, L ;

Carlsson, L ;

Edlund, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6395-6403

[4]

Brandon L., Two Distinct High Throughput Screens of PAS Kinase Yield Convergent Insight to Enzyme Function

[5] Consistent patterns of rate asymmetry and gene loss indicate widespread neofunctionalization of yeast genes after whole-genome duplication [J].

Byrne, Kevin P. ;

Wolfe, Kenneth H. .

GENETICS, 2007, 175 (03) :1341-1350

[6] The mouse kinome: Discovery and comparative genomics of all mouse protein kinases [J].

Caenepeel, S ;

Charydczak, G ;

Sudarsanam, S ;

Hunter, T ;

Manning, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11707-11712

[7] PAS Kinase Promotes Cell Survival and Growth Through Activation of Rho1 [J].

Cardon, Caleb M. ;

Beck, Thomas ;

Hall, Michael N. ;

Rutter, Jared .

SCIENCE SIGNALING, 2012, 5 (209)

[8] The regulation of protein function by multisite phosphorylation - a 25 year update [J].

Cohen, P .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (12) :596-601

[9] Increased glycolytic flux as an outcome of whole-genome duplication in yeast [J].

Conant, Gavin C. ;

Wolfe, Kenneth H. .

MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1)

[10] Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose [J].

da Silva Xavier, G ;

Rutter, J ;

Rutter, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (22) :8319-8324

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