Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Cocamidopropyl betaine (CAPB)

被引：44

作者：

Burnett, Christina L. ^{[1
]}

Bergfeld, Wilma F.

Belsito, Donald V.

Hill, Ronald A.

Klaassen, Curtis D.

Liebler, Daniel

Marks, James G., Jr.

Shank, Ronald C.

Slaga, Thomas J.

Snyder, Paul W.

Andersen, F. Alan ^{[1
]}

机构：

[1] Cosmet Ingredient Rev, Washington, DC 20036 USA

来源：

INTERNATIONAL JOURNAL OF TOXICOLOGY | 2012年 / 31卷

关键词：

cocamidopropyl betaine; CAPB; cosmetics; safety; CONTACT ALLERGY; PATCH TEST; 3-DIMETHYLAMINOPROPYLAMINE; SENSITIZATION; REACTIVITY; SURFACTANTS; AMIDOAMINE; CARRIER;

D O I：

10.1177/1091581812447202

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cocamidopropyl betaine (CAPB) and related amidopropyl betaines are zwitterions used mainly as surfactants in cosmetics. These cosmetic ingredients are similar in their chemistry, in particular with respect to the presence of 3,3-dimethylamino-propylamine (DMAPA) and fatty acid amidopropyl dimethylamine (amidoamine) impurities, which are known as sensitizers. The CIR Expert Panel concluded that because these ingredients present no other significant toxicity, when formulated to be nonsensitizing (which may be based on a quantitative risk assessment), these ingredients are safe for use as cosmetic ingredients in the practices of use and concentration of this safety assessment.

引用

页码：77S / 111S

页数：35

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