In vitro antitumor activity of titanocene alanine complex and its interaction with nucleic acids

被引：0
|
作者：
Zhang, ZG [1 ]
Jin, L [1 ]
Yang, P [1 ]
机构：
[1] SHANXI UNIV,INST MOL SCI,TAIYUAN 030006,SHANXI,PEOPLES R CHINA
来源：
CHINESE JOURNAL OF CHEMISTRY | 1997年 / 15卷 / 03期
关键词：
titanocene alanine complex; DNA; antitumor;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Titanocene alanine complex, Cp2Ti(O2CCH(CH3)NH3+Cl-)(2), has been found to have in vitro antitumor activity against Ehrlich ascites tumor cells. Study of the interaction between Cp2Ti(O2CCH(CH3)NH3+Cl-)(2) and DNA by UV-VIS spectra, fluorescence spectra, agarose gel electrophoresis reveals that Cp2Ti(O2CCH(CH3)NH3+Cl-)(2) forms a stable compound with DNA in molar ratio 1:1 and reduces the migration rate of ccc-DNA band and oc-DNA band. However, unlike cisplatin, the complex does not induce nicking of DNA even after a long incubation at a high ratio of the complex to DNA. The results suggest that titanocene-based antitumor agents have different mechanism of action from cisplatin-like antitumor agents.
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页码：225 / 233
页数：9
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