Effects of Melaxen and Valdoxan on Superoxide Dismutase and Catalase Activities in Experimental Hyperthyroidism

被引：1
|
作者：
Gorbenko, M. V. [1 ]
Popova, T. N. [1 ]
Shul'gin, K. K. [1 ]
Popov, S. S. [2 ]
机构：
[1] Voronezh State Univ, Voronezh 394693, Russia
[2] NN Burdenko Voronezh State Med Acad, Voronezh, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 47卷 / 11期
关键词：
Hyperthyroidism; free radical oxidation; Melaxen; Valdoxan; superoxide dismutase; catalase; OXIDATIVE STRESS; MELATONIN;
D O I：
10.1007/s11094-014-1010-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effects of Melaxen and Valdoxan on measures of biochemiluminescence (BCL) were studied on the background of the development of experimental hyperthyroidism in terms of the light sum of chemiluminescence (S) and the maximum peak intensity (I (max)), which characterize the intensity of free radical processes, and the tangent of the kinetic curve slope (tg alpha 2), which reflects total antioxidant activity; effects on superoxide dismutase and catalase activities in tissues and serum were also studied. Increases in these measures due to oxidative stress in experimental hyperthyroidism were found to normalize in response to these agents.
引用
收藏
页码：577 / 580
页数：4
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