Ci - a complex transducer of the Hedgehog signal

被引：139

作者：

Aza-Blanc, P ^{[1
]}

Kornberg, TB ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 11期

关键词：

D O I：

10.1016/S0168-9525(99)01869-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent progress has unveiled Cubitus interruptus (Ci) as a complex transcription factor whose diverse activities as an activator and repressor are regulated by its proteolysis, localization and concentration. The principal role of Ci is to elaborate the developmental program directed by the morphogen Hedgehog (Hh), and it uses its various activities to target the expression of key downstream genes to different spatial domains. Here, we highlight recent advances in the Ci story, and discuss remaining questions whose resolution promise to help explain how morphogens like Hh signal their distant targets.

引用

页码：458 / 462

页数：5

共 58 条

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