Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity

被引：33
|
作者：
Choodej, Siwattra [1 ]
Sommit, Damrong [2 ]
Pudhom, Khanitha [1 ]
机构：
[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand
[2] Mahanakorn Univ Technol, Fac Sci, Dept Chem, Bangkok 10530, Thailand
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 13期
关键词：
Harrisonia perforata; Rearranged limonoid; Chromone; Anti-inflammatory; NF-KAPPA-B; CYTOKINES;
D O I：
10.1016/j.bmcl.2013.04.064
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new rearranged limonoids, harperforatin (1) and harperfolide (2), and a new chromone, harperamone (3), were isolated from fruits and roots of Harrisonia perforata, together with eight known compounds. Their structures were elucidated on the basis of spectroscopic data. Harperfolide (2) exhibited potent anti-inflammatory activity by suppressing nitric oxide (NO) production from activated macrophages with IC50 value of 6.51 mu M. Furthermore, its effect is mediated by reduction of iNOS protein expression, attributable to the inhibitory action of LPS-induced NO production. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3896 / 3900
页数：5
相关论文
共 50 条
  • [1] New rearranged limonoids from Harrisonia perforata
    Khuong-Huu, Q
    Chiaroni, A
    Riche, C
    Nguyen-Ngoc, H
    Nguyen-Viet, K
    Khuong-Huu, F
    JOURNAL OF NATURAL PRODUCTS, 2000, 63 (07): : 1015 - 1018
  • [2] Haperforatones A-M, thirteen undescribed limonoids from Harrisonia perforata with anti-inflammatory activity
    Wang, Qing
    Wu, Zhitao
    Li, Chenyue
    Qin, Guoqing
    Hu, Xianggang
    Guo, Pengju
    Ding, Aoxue
    Xu, Wenjing
    Wang, Wenqiong
    Xuan, Lijiang
    BIOORGANIC CHEMISTRY, 2024, 151
  • [3] New rearranged limonoids from Harrisonia perforata.: III
    Khuong-Huu, Q
    Chiaroni, A
    Riche, C
    Nguyen-Ngoc, H
    Nguyen-Viet, K
    Khuong-Huu, F
    JOURNAL OF NATURAL PRODUCTS, 2001, 64 (05): : 634 - 637
  • [4] Enantiomeric chromones from Harrisonia perforata
    Liu, Guo
    Zheng, Rong-Rong
    Liu, Zhi-Wen
    Wang, Wen-Jing
    Li, Guo-Qiang
    Fan, Chun-Lin
    Zhang, Xiao-Qi
    Ye, Wen-Cai
    Che, Chun-Tao
    PHYTOCHEMISTRY LETTERS, 2014, 10 : 295 - 299
  • [5] Quassinoids and limonoids from Harrisonia perforata
    Kamiuchi, K
    Mitsunaga, K
    Koike, K
    Ouyang, Y
    Ohmoto, T
    Nikaido, T
    HETEROCYCLES, 1996, 43 (03) : 653 - 664
  • [6] Chromones from stems of Harrisonia perforata
    Khumsubdee, Sakunchai
    Prachyawarakorn, Vilailak
    Mahidol, Chulabhorn
    Ploypradith, Poonsakdi
    Ruchirawat, Somsak
    Pailee, Phanruethai
    NATURAL PRODUCT RESEARCH, 2025,
  • [7] CHROMONES FROM HARRISONIA-PERFORATA
    TANAKA, T
    KOIKE, K
    MITSUNAGA, K
    NARITA, K
    TAKANO, S
    KAMIOKA, A
    SASE, E
    OUYANG, Y
    OHMOTO, T
    PHYTOCHEMISTRY, 1995, 40 (06) : 1787 - 1790
  • [8] Isoprenylated chromones from the stems of Harrisonia perforata
    Cheenpracha, Sarot
    Chokchaisiri, Ratchanaporn
    Ganranoo, Lucksagoon
    Maneerat, Tharakorn
    Rujanapun, Narawadee
    Charoensup, Rawiwan
    Laphookhieo, Surat
    Injan, Natcha
    Nokbin, Somkiat
    PHYTOCHEMISTRY LETTERS, 2022, 49 : 192 - 196
  • [9] CHROMONES FROM HARRISONIA-PERFORATA (BLANCO) MERR
    THADANITI, S
    ARCHAKUNAKORN, W
    TUNTIWACHWUTTIKUL, P
    BREMNER, JB
    JOURNAL OF THE SCIENCE SOCIETY OF THAILAND, 1994, 20 (04): : 183 - 187
  • [10] CHROMONES AND LIMONOIDS FROM HARRISONIA-ABYSSINICA
    OKORIE, DA
    PHYTOCHEMISTRY, 1982, 21 (09) : 2424 - 2426
12345