Emerging links between m6A and misregulated mRNA methylation in cancer

被引：90

作者：

Jaffrey, Samie R. ^{[1
]}

Kharas, Michael G. ^{[2
]}

机构：

[1] Cornell Univ, Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Mol Pharmacol Program, New York, NY 10021 USA

来源：

GENOME MEDICINE | 2017年 / 9卷

关键词：

Myeloid Leukemia; Cancer Stem Cell; Breast Cancer Stem Cell; Cancer Stem Cell Phenotype; Methylation Complex;

D O I：

10.1186/s13073-016-0395-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

N-6-methyladenosine (m(6)A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeutic avenue for investigation.

引用

页数：3

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