Temporal changes of adiponectin plasma levels in patients with acute ischemic stroke

被引：11

作者：

Pera, Joanna ^{[1
]}

Dziedzic, Tomasz ^{[1
]}

Szczudlik, Andrzej ^{[1
]}

Slowik, Agnieszka ^{[1
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Neurol, PL-31503 Krakow, Poland

来源：

NEUROLOGICAL RESEARCH | 2013年 / 35卷 / 09期

关键词：

Acute ischemic stroke; Adiponectin; Temporal expression; Plasma; Human; ACUTE MYOCARDIAL-INFARCTION; CEREBROVASCULAR-DISEASE; CEREBRAL INFARCTION; REPERFUSION INJURY; HYPOADIPONECTINEMIA; RISK; ADIPOCYTOKINES; ASSOCIATION; MEN;

D O I：

10.1179/1743132813Y.0000000241

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Adiponectin, an adipocyte-derived hormone, possesses anti-inflammatory properties. Its decreased levels were noted in patients with ischemic stroke (IS). Animal studies suggest that the decline of adiponectin levels in the acute IS phase is a dynamic process. The aim of the present study was to analyze the temporal expression of the adiponectin plasma levels in patients with acute IS. Thirty-one consecutive patients with first-ever IS (mean age +/- SD: 69.5 +/- 12.5 years; 12 women) and 26 control subjects (CS; 72.2 +/- 7.6 years; 18 women) were included into the study. Plasma adiponectin levels were measured at three time points: within first 24 hours, on Days 2-4, and on Days 5-10 days after the onset of IS. Adiponectin levels were significantly lower in IS patients on admission comparing with CS (medians: 6.0 mu g/ml vs. 11.3 mu g/ml, respectively; P < 0.05) and continued to decline at later time points (P < 0.001).

引用

页码：988 / 991

页数：4

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