Synthesis and hyperpolarized 15N NMR studies of 15N-choline-d13

被引：16
|
作者：
Kumagai, Keiko [1 ]
Kawashima, Kazuyasu [1 ]
Akakabe, Mai [1 ]
Tsuda, Masayuki [1 ]
Abe, Takamasa [2 ]
Tsuda, Masashi [3 ]
机构：
[1] Kochi Univ, Ctr Sci Res, Kochi 7838505, Japan
[2] Oxford Instrument KK, NanoSci Div, Tokyo 1350047, Japan
[3] Kochi Univ, Ctr Adv Marine Core Res, Kochi 7838502, Japan
来源：
TETRAHEDRON | 2013年 / 69卷 / 19期
关键词：
Choline; Dynamic nuclear polarization; C-13; MAGNETIC-RESONANCE; DYNAMIC NUCLEAR-POLARIZATION; PROSTATE-CANCER; SPECTROSCOPY; METABOLISM; CHOLINE; TUMORS; TIMES;
D O I：
10.1016/j.tet.2013.03.043
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-15-Choline-d(13) was synthesized as a new biomarker for dynamic nuclear polarization, and the lifetime of the polarized signal governed by the spin-lattice relaxation time T-1 was measured. N-15-Choline-d(13) exhibited a T-1 that was over twice as long as that of N-15-choline, and the hyperpolarized N-15 signal could be observed for 1 h. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3896 / 3900
页数：5
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