The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis

被引:31
作者
Muloiwa, Rudzani [1 ]
Kagina, Benjamin M. [2 ]
Engel, Mark E. [3 ]
Hussey, Gregory D. [2 ,4 ,5 ]
机构
[1] Univ Cape Town, Groote Schuur Hosp, Dept Paediat & Child Hlth, Main Rd, ZA-7925 Cape Town, South Africa
[2] Univ Cape Town, Sch Publ Hlth & Family Med, Vaccines Africa Initiat, Anzio Rd, ZA-7925 Cape Town, South Africa
[3] Univ Cape Town, Groote Schuur Hosp, Dept Med, Main Rd, ZA-7925 Cape Town, South Africa
[4] Univ Cape Town, Div Med Microbiol, Anzio Rd, ZA-7925 Cape Town, South Africa
[5] Univ Cape Town, Inst Infect Dis & Mol Med, Anzio Rd, ZA-7925 Cape Town, South Africa
关键词
Pertussis; Burden; Prevalence; Incidence; Mortality; Case fatality; HIV; Low; and middle-income countries (LMIC); COMMUNITY-ACQUIRED PNEUMONIA; POLYMERASE-CHAIN-REACTION; BORDETELLA-PERTUSSIS; WHOOPING-COUGH; HOSPITALIZED INFANTS; PROLONGED COUGH; GLOBAL BURDEN; RISK-FACTORS; SAO-PAULO; CHILDREN;
D O I
10.1186/s12916-020-01699-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background An effective vaccine againstBordetella pertussiswas introduced into the Expanded Programme on Immunisation (EPI) by WHO in 1974, leading to a substantial global reduction in pertussis morbidity and mortality. In low- and middle-income countries (LMICs), however, the epidemiology of pertussis remains largely unknown. This impacts negatively on pertussis control strategies in these countries. This study aimed to systematically and comprehensively review published literature on the burden of laboratory-confirmed pertussis in LMICs over the 45 years of EPI. Methods Electronic databases were searched for relevant literature (1974 to December 2018) using common and MeSH terms for pertussis. Studies using PCR, culture or paired serology to confirmBordetella pertussisandparapertussisin symptomatic individuals were included if they had clearly defined numerators and denominators to determine prevalence and mortality rates. Results Eighty-two studies (49,167 participants) made the inclusion criteria. All six WHO regions were represented with most of the studies published after 2010 and involving mainly upper middle-income countries (n = 63; 77%). PCR was the main diagnostic test after the year 2000. The overall median point prevalence of PCR-confirmedBordetella pertussiswas 11% (interquartile range (IQR), 5-27%), while culture-confirmed was 3% (IQR 1-9%) and paired serology a median of 17% (IQR 3-23%) over the period. On average, culture underestimated prevalence by 85% (RR = 0.15, 95% CI, 0.10-0.22) compared to PCR in the same studies. Risk of pertussis increased with HIV exposure [RR, 1.4 (95% CI, 1.0-2.0)] and infection [RR, 2.4 (95% CI, 1.1-5.1)]. HIV infection and exposure were also related to higher pertussis incidences, higher rates of hospitalisation and pertussis-related deaths. Pertussis mortality and case fatality rates were 0.8% (95% CI, 0.4-1.4%) and 6.5% (95% CI, 4.0-9.5%), respectively. Most deaths occurred in infants less than 6 months of age. Conclusions Despite the widespread use of pertussis vaccines, the prevalence of pertussis remains high in LMIC over the last three decades. There is a need to increase access to PCR-based diagnostic confirmation in order to improve surveillance. Disease control measures in LMICs must take into account the persistent significant infant mortality and increased disease burden associated with HIV infection and exposure.
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共 114 条
[31]  
Dumaidi K, 2018, ARCH IRAN MED, V21, P208
[32]   Detection of Bordetella pertussis using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals [J].
Esther Castillo, Maria ;
Bada, Carlos ;
del Aguila, Olguita ;
Petrozzi-Helasvuo, Veronica ;
Casabona-Ore, Veronica ;
Reyes, Isabel ;
del Valle-Mendoza, Juana .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2015, 41 :36-41
[33]   Respiratory viral infections in infants with clinically suspected pertussis [J].
Ferronato, Angela E. ;
Gilio, Alfredo E. ;
Vieira, Sandra E. .
JORNAL DE PEDIATRIA, 2013, 89 (06) :549-553
[34]   Sensitivity and specificity of the World Health Organization pertussis clinical case definition [J].
Ghanaie, Roxana Mansour ;
Karimi, Abdollah ;
Sadeghi, Hossein ;
Esteghamti, Abdolreza ;
Falah, Fateme ;
Armin, Shahnaz ;
Fahimzad, Alireza ;
Shamshiri, Ahmadreza ;
Kahbazi, Manige ;
Shiva, Faride .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2010, 14 (12) :E1072-E1075
[35]  
Ghorbani Golam Reza, 2016, Osong Public Health Res Perspect, V7, P131, DOI 10.1016/j.phrp.2016.02.004
[36]  
Giayetto VO, 2017, REV CHIL INFECTOL, V34, P108, DOI 10.4067/S0716-10182017000200002
[37]   Incidence of Severe and Nonsevere Pertussis Among HIV-Exposed and -Unexposed Zambian Infants Through 14 Weeks of Age: Results From the Southern Africa Mother Infant Pertussis Study (SAMIPS), a Longitudinal Birth Cohort Study [J].
Gill, Christopher J. ;
Mwananyanda, Lawrence ;
MacLeod, William ;
Kwenda, Geoffrey ;
Mwale, Magdalene ;
Williams, Anna L. ;
Siazeele, Kazungu ;
Yang, Zhaoyan ;
Mwansa, James ;
Thea, Donald M. .
CLINICAL INFECTIOUS DISEASES, 2016, 63 :S154-S164
[38]   Maternal vaccination against pertussis: a systematic review of the recent literature [J].
Gkentzi, Despoina ;
Katsakiori, Paraskeui ;
Marangos, Markos ;
Hsia, Yingfen ;
Amirthalingam, Gayatri ;
Heath, Paul T. ;
Ladhani, Shamez .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2017, 102 (05) :F456-F463
[39]   Bordetella Pertussis Infection in Hospitalized Infants with Acute Bronchiolitis [J].
Gokce, Sule ;
Kurugol, Zafer ;
Aydemir, S. Sohret ;
Cicek, Candan ;
Aslan, Asli ;
Koturoglu, Guldane .
INDIAN JOURNAL OF PEDIATRICS, 2018, 85 (03) :189-193
[40]   Prevalence and Seasonal Distribution of Respiratory Viruses During the 2014-2015 Season in Istanbul [J].
Goktas, Safak ;
Sirin, Mumtaz Cem .
JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 2016, 9 (09)