C-reactive protein (CRP) after revascularized STEMI: Is CRP a prognostic factor?

Purpose. - During myocardial infarction (MI), numerous biomarkers increase, such as troponin (necrosis), BNP, and high sensibility C-reactive protein (hsCRP) (inflammation). The objectives of the Study Were to Study kinetics of hsCRP after a revascularized MI, and correlations between hsCRP and clinical outcomes or biological markers, and prognostic value of CRP. Patients and methods. - Fifty-two patients were admitted for STEW (ST segment Elevation MI). Primary coronarography interventions (PCI) were performed for urgent reperfusion. Patients were included only in case Of Success TIMI 3). Clinical examination was completed by a biological follow-up of BNP. troponin-1 (before and after PCI, days 1, 2, 3, 6) and hsCRP (days 0, 1, 2, 3, 6). Clinical outcomes follow-up was performed during hospitalization, on the first month, and the sixth month. Results. - hsCRP increases during the first days (peak on (lay 3: 46.1 mg/L), and decreases between the third and the seventh day. Clinical outcomes were correlated with CRP: door-to-balloon time, age, creatinin level oil admission. During follow-up, there were clinical events in 13/49 (26%) of the patients. Among them, hsCRP oil day 2 was higher (p < 0.0001), compared to other patients. Compared to other biological markers, hsCRP was correlated with BNP on days 2 and 3 (p = 0.0081). Conclusion. - hsCRP increases after revascularized STEMI in accordance to the infact size, in the first days. hsCRP is correlated with cardiovascular pronostic biomarkers. hsCRP Could play ail active role, and could be used as a pronostic biomarker after revascularized STEMI, which are usually considered as a low-risk population. (C) 2008 Elsevier Masson SAS. Tous droits reserves.