Solubility of Salicylic Acid, Salicylamide, and Fenofibrate in Organic Solvents at Low Temperatures

被引：12

作者：

Sadeghi, Masoud ^{[1
]}

Rasmuson, Ake C. ^{[1
]}

机构：

[1] Univ Limerick, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Dept Chem & Environm Sci, Limerick V94 T9PX, Ireland

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2020年 / 65卷 / 10期

基金：

爱尔兰科学基金会;

关键词：

MELTING PROPERTIES; CRYSTALLIZATION;

D O I：

10.1021/acs.jced.0c00443

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

In the present work, the solubility of salicylic acid, salicylamide, and fenofibrate (form I) has been determined in acetone, acetonitrile, ethyl acetate, and methanol in the range of -30 to +10 degrees C. Salicylic acid and salicylamide have the highest solubility in acetone and the lowest in acetonitrile. Fenofibrate has the highest solubility in ethyl acetate and the lowest in methanol. In all solvents except for acetonitrile, the solubility of salicylic acid is higher than the solubility of the other two compounds. In all solvents except for ethyl acetate, the solubility of fenofibrate is lower than the solubility of the other two compounds. In all cases, the solubility increases with increasing temperature and agrees well with the previously published data at higher temperatures. Finally, an empirical equation is fitted to the experimental

引用

页码：4855 / 4861

页数：7

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