Optically clear alginate hydrogels for spatially controlled cell entrapment and culture at microfluidic electrode surfaces

被引：39

作者：

Betz, Jordan F. ^{[1
,2
]}

Cheng, Yi ^{[2
,3
]}

Tsao, Chen-Yu ^{[4
]}

Zargar, Amin ^{[1
,4
]}

Wu, Hsuan-Chen ^{[4
]}

Luo, Xiaolong ^{[4
]}

Payne, Gregory F. ^{[1
,4
]}

Bentleyad, William E. ^{[1
,4
]}

Rubloff, Gary W. ^{[2
,3
]}

机构：

[1] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA

[2] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA

[3] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA

[4] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA

来源：

LAB ON A CHIP | 2013年 / 13卷 / 10期

关键词：

D O I：

10.1039/c3lc50079a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe an innovation in the immobilization, culture, and imaging of cells in calcium alginate within microfluidic devices. This technique allows unprecedented optical access to the entirety of the calcium alginate hydrogel, enabling observation of growth and behavior in a chemical and mechanical environment favored by many kinds of cells.

引用

页码：1854 / 1858

页数：5

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