SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD

被引：12
|
作者：
Zhang, Li [1 ]
Luo, Bailing [2 ]
Ting, Yuan [3 ,4 ]
He, Shengyang [1 ]
Xie, Lihua [1 ]
Sun, Shenghua [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 3, Dept Resp Med, Changsha 410013, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Pulm & Crit Care Med, Changsha 410008, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Hosp 2, Dept Emergency Med, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Difficult Dis Inst, Changsha, Hunan, Peoples R China
来源：
GROWTH FACTORS | 2020年 / 38卷 / 02期
关键词：
Chronic obstructive disease; sirtuin1; endoplasmic reticulum stress; alveolar epithelial cells; apoptosis; CIGARETTE-SMOKE; CHAPERONE ORP150; EPITHELIAL-CELLS; RESVERATROL; PROTECTS; INDUCTION; REDUCTION; EMPHYSEMA; INJURY;
D O I：
10.1080/08977194.2020.1810029
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The present study aimed to investigate the protective role of sirtuin 1 (SIRT1) and oxygen regulated protein 150 (ORP150) in a rat COPD model by inducing changes in ER stress and apoptosis. We separated 48 Sprague Dawley (SD) rats into four groups randomly: the control group, resveratrol group, COPD group and the resveratrol intervention group. Rats were challenged with cigarette smoke and lipopolysaccharide with resveratrol (a selective activator of SIRT1). The lung functions of the rats were measured and recorded. The expression levels of SIRT1 and ORP150 in lung tissues were examined by western blot and RTq PCR. The expression levels of the ER stress apoptosis-associated protein were determined .The apoptotic level of lung tissues was analyzed. The results suggest that SIRT1 attenuated apoptosis and ER stress in the lung tissues of rats with COPD. During this process, a positive correlation was identified between SIRT1 and ORP150.
引用
收藏
页码：94 / 104
页数：11
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