Crosslinked QA-PEI nanoparticles: synthesis reproducibility, chemical modifications, and stability study

被引：20

作者：

Farah, Shady ^{[1
,2
]}

Khan, Wahid ^{[1
,2
]}

Farber, Ira ^{[1
,2
]}

Kesler-Shvero, Dana ^{[3
]}

Beyth, Nurit ^{[3
]}

Weiss, Ervin I. ^{[3
]}

Domb, Abraham J. ^{[1
,2
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Ctr Nanosci & Nanotechnol, Inst Drug Res,Fac Med, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Alex Grass Ctr Drug Design & Synth, IL-91120 Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Dept Prosthodont, Fac Dent, IL-91120 Jerusalem, Israel

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2013年 / 24卷 / 05期

关键词：

nanoparticles; antimicrobial dental composite; polyethylenimine; antimicrobial surface; BIOLOGICALLY-ACTIVE POLYMERS; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; QUATERNARY AMMONIUM; RESIN COMPOSITES; BIOCOMPATIBILITY; CONTACT;

D O I：

10.1002/pat.3102

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Quaternary ammonium polyethylenimine (QA-PEI) nanoparticles were synthesized by PEI crosslinking and alkylation with octyliodide followed by quaternization by methyl iodide. The present study focuses on the reproducibility of particles formation with respect to particle size, positive charge, oxidative, thermal stability and antibacterial activity. The QA-PEI-based nanoparticles with particle size in the range of 160190nm were synthesized in high reproducibility and showed high chemical stability against environmental changes including exposure to different oxidizers and storage conditions. QA-PEI nanoparticles incorporated in dental restorative resin composites at 2% w/w demonstrated strong antibacterial activity. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：446 / 452

页数：7

共 32 条

[1] Preparation and investigation of antibacterial carbohydrate-based surfaces
Abel, T
Cohen, JI
Engel, R
Filshtinskaya, M
Melkonian, A
Melkonian, K
[J]. CARBOHYDRATE RESEARCH, 2002, 337 (24) : 2495 - 2499
[2] Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans
Beyth, N
Yudovin-Farber, I
Bahir, R
Domb, AJ
Weissa, E
[J]. BIOMATERIALS, 2006, 27 (21) : 3995 - 4002
[3] Beyth N, 2010, P NATL ACAD SCI USA, V107
[4] Surface antimicrobial activity and biocompatibility of incorporated polyethylenimine nanoparticles
Beyth, Nurit
Houri-Haddad, Yael
Baraness-Hadar, Liat
Yudovin-Farber, Ira
Domb, Abraham J.
Weiss, Ervin I.
[J]. BIOMATERIALS, 2008, 29 (31) : 4157 - 4163
[5] Beyth N, 2010, QUINTESSENCE INT, V41, P827
[6] Antibacterial activity of restorative dental biomaterials in vitro
Boeckh, C
Schumacher, E
Podbielski, A
Haller, B
[J]. CARIES RESEARCH, 2002, 36 (02) : 101 - 107
[7] Synthesis and characterization of novel antimicrobial cationic polyelectrolytes
Cakmak, I
Ulukanli, Z
Tuzcu, M
Karabuga, S
Genctav, K
[J]. EUROPEAN POLYMER JOURNAL, 2004, 40 (10) : 2373 - 2379
[8] Bacterial biofilms: A common cause of persistent infections
Costerton, JW
Stewart, PS
Greenberg, EP
[J]. SCIENCE, 1999, 284 (5418) : 1318 - 1322
[9] Cotton, 1964, PROGR INORGANIC CHEM
[10] Synthesis and antimicrobial activities of new water-soluble bis-quaternary ammonium methacrylate polymers
Dizman, B
Elasri, MO
Mathias, LJ
[J]. JOURNAL OF APPLIED POLYMER SCIENCE, 2004, 94 (02) : 635 - 642

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