Physiochemical Characteristics of Poly-L-Lactic Acid (PLLA)

被引:129
作者
Fitzgerald, Rebecca
Bass, Lawrence M. [1 ]
Goldberg, David J. [2 ]
Graivier, Miles H.
Lorenc, Z. Paul
机构
[1] Manhattan Eye Ear & Throat Hosp, Dept Plast Surg, Plast Surg, Zucker Sch Med Hofstra Northwell, New York, NY 10021 USA
[2] Icahn Sch Med Mt Sinai, Dept Dermatol, Dermatol, New York, NY 10029 USA
关键词
AGING FACE; POLYLACTIC ACID; DERMAL FILLER; RESTORATION;
D O I
10.1093/asj/sjy012
中图分类号
R61 [外科手术学];
学科分类号
摘要
Poly-L-lactic acid (PLLA) is a synthetic, biocompatible, biodegradable polymer. For soft-tissue augmentation, the size and chemical attributes of the PLLA microparticles are central to this agent's ability to promote a subclinical inflammatory response that stimulates deposition of collagen in the extracellular matrix. The resultant restoration of facial volume occurs in a controlled, predictable manner and is long lasting. The unique physiochemical and biostimulatory properties of PLLA differentiate it from other available treatments and are the foundation of the unique treatment methodology required for optimal results.
引用
收藏
页码:S13 / S17
页数:5
相关论文
共 24 条
[1]  
[Anonymous], 2013, RADIESSE INJ IMPL IN
[2]   Facial volume restoration of the aging face with poly-l-lactic acid [J].
Fitzgerald, Rebecca ;
Vleggaar, Danny .
DERMATOLOGIC THERAPY, 2011, 24 (01) :2-27
[3]  
Galderma Laboratories, 2016, SCULPTRA AESTH INJ P
[4]   TISSUE-RESPONSE AND IN-VIVO DEGRADATION OF SELECTED POLYHYDROXYACIDS - POLYLACTIDES (PLA), POLY(3-HYDROXYBUTYRATE) (PHB), AND POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYVALERATE) (PHB/VA) [J].
GOGOLEWSKI, S ;
JOVANOVIC, M ;
PERREN, SM ;
DILLON, JG ;
HUGHES, MK .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1993, 27 (09) :1135-1148
[5]   All charged up about implanted biomaterials [J].
Grainger, David W. .
NATURE BIOTECHNOLOGY, 2013, 31 (06) :507-509
[6]   Late-onset, recurrent facial nodules associated with injection of poly-L-lactic acid [J].
Hamilton, Douglas G. ;
Gauthier, Nelly ;
Robertson, Brent F. .
DERMATOLOGIC SURGERY, 2008, 34 (01) :123-126
[7]  
KULKARNI RK, 1966, ARCH SURG-CHICAGO, V93, P839
[8]   Human histology and persistence of various injectable filler substances for soft tissue augmentation [J].
Lemperle, G ;
Morhenn, V ;
Charrier, U .
AESTHETIC PLASTIC SURGERY, 2003, 27 (05) :354-366
[9]   ArteFill: A third-generation permanent dermal filler and tissue stimulator [J].
Lemperle, Gottfried ;
de Fazio, Stefania ;
Nicolau, Pierre .
CLINICS IN PLASTIC SURGERY, 2006, 33 (04) :551-+
[10]  
Lorenc ZP, 2016, J DRUGS DERMATOL, V15, P1136