The Late Na+ Current - Origin and Pathophysiological Relevance

被引:39
作者
Zaza, Antonio [1 ]
Rocchetti, Marcella [1 ]
机构
[1] Univ Milano Bicocca, Dipartimento Biotecnol & Biosci, I-20126 Milan, Italy
关键词
I-NaL; Repolarization reserve; Ca2+ mishandling; Arrhythmias; Metabolic dysfunction; LATE SODIUM CURRENT; FATTY-ACID OXIDATION; VENTRICULAR MYOCYTES; EARLY AFTERDEPOLARIZATIONS; CHANNEL MUTATIONS; HEART; RANOLAZINE; MECHANISM; CA2+; HYPERTROPHY;
D O I
10.1007/s10557-012-6430-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:61 / 68
页数:8
相关论文
共 64 条
  • [1] AbdAlla Said, 2011, Cardiovascular & Hematological Agents in Medicinal Chemistry, V9, P190
  • [2] Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins
    Abriel, H
    Kass, RS
    [J]. TRENDS IN CARDIOVASCULAR MEDICINE, 2005, 15 (01) : 35 - 40
  • [3] Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts
    Aldakkak, Mohammed
    Camara, Amadou K. S.
    Heisner, James S.
    Yang, Meiying
    Stowe, David F.
    [J]. PHARMACOLOGICAL RESEARCH, 2011, 64 (04) : 381 - 392
  • [4] Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
    Antzelevitch, C
    Belardinelli, L
    Zygmunt, AC
    Burashnikov, A
    Di Diego, JM
    Fish, JM
    Cordeiro, JM
    Thomas, G
    [J]. CIRCULATION, 2004, 110 (08) : 904 - 910
  • [5] Electrophysiologic basis for the antiarrhythmic actions of ranolazine
    Antzelevitch, Charles
    Burashnikov, Alexander
    Sicouri, Serge
    Belardinelli, Luiz
    [J]. HEART RHYTHM, 2011, 8 (08) : 1281 - 1290
  • [6] STEADY-STATE TTX-SENSITIVE (WINDOW) SODIUM CURRENT IN CARDIAC PURKINJE-FIBERS
    ATTWELL, D
    COHEN, I
    EISNER, D
    OHBA, M
    OJEDA, C
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1979, 379 (02): : 137 - 142
  • [7] MOLECULAR MECHANISM FOR AN INHERITED CARDIAC-ARRHYTHMIA
    BENNETT, PB
    YAZAWA, K
    MAKITA, N
    GEORGE, AL
    [J]. NATURE, 1995, 376 (6542) : 683 - 685
  • [8] Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique
    Berecki, G
    Zegers, JG
    Bhuiyan, ZA
    Verkerk, AO
    Wilders, R
    van Ginneken, ACG
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2006, 570 (02): : 237 - 250
  • [9] Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes
    Bers, Donald M.
    Despa, Sanda
    Bossuyt, Julie
    [J]. INTERACTIVE AND INTEGRATIVE CARDIOLOGY, 2006, 1080 : 165 - 177
  • [10] Non-equilibrium Gating in cardiac Na+ channels -: An original mechanism of arrhythmia
    Clancy, CE
    Tateyama, M
    Liu, HJ
    Wehrens, XHT
    Kass, RS
    [J]. CIRCULATION, 2003, 107 (17) : 2233 - 2237