Three-Component Reaction of Propargyl Amines, Sulfonyl Azides, and Alkynes: One-Pot Synthesis of Tetrasubstituted Imidazoles

被引：96

作者：

Jiang, Zheng ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 24期

关键词：

FACILE ACCESS; MULTICOMPONENT REACTIONS; OXIDATIVE AROMATIZATION; AZEPINE DERIVATIVES; EFFICIENT SYNTHESIS; CASCADE REACTIONS; AMIDE SYNTHESIS; RING CLOSURES; CYCLOISOMERIZATION; HYDROAMINATION;

D O I：

10.1021/ol303023y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-Sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.

引用

页码：6266 / 6269

页数：4

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