Three-Component Reaction of Propargyl Amines, Sulfonyl Azides, and Alkynes: One-Pot Synthesis of Tetrasubstituted Imidazoles

被引：96
|
作者：
Jiang, Zheng [1 ]
Lu, Ping [1 ]
Wang, Yanguang [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 24期
关键词：
FACILE ACCESS; MULTICOMPONENT REACTIONS; OXIDATIVE AROMATIZATION; AZEPINE DERIVATIVES; EFFICIENT SYNTHESIS; CASCADE REACTIONS; AMIDE SYNTHESIS; RING CLOSURES; CYCLOISOMERIZATION; HYDROAMINATION;
D O I：
10.1021/ol303023y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-Sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.
引用
收藏
页码：6266 / 6269
页数：4
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