Management of Nontuberculous Mycobacterial (NTM) Lung Disease

被引:24
作者
Philley, Julie V. [1 ]
Griffith, David E. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr, Dept Med, Div Pulm & Crit Care Med, Tyler, TX 75708 USA
关键词
Mycobacterium abscessus; Mycobacterium avium complex; nontuberculous mycobacteria; AVIUM COMPLEX DISEASE; CLINICAL-RELEVANCE; PULMONARY-DISEASE; MACROLIDE RESISTANCE; TREATMENT REGIMENS; CLARITHROMYCIN; AZITHROMYCIN; PREVALENCE; ETHAMBUTOL; ABSCESSUS;
D O I
10.1055/s-0033-1333575
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Nontuberculous mycobacterial (NTM) lung diseases present formidable obstacles to successful management, especially when compared with tuberculosis, beginning with diagnosis and extending through treatment. Factors peculiar to NTM disease such as extensive microbial resistance mechanisms and difficult to interpret, even misleading, in vitro drug susceptibility patterns are just two of the multiple and frustrating clinical management challenges. More conventional problems such as drug-drug interactions, medication side-effects, and nonadherence with therapy add further impediments to successful outcomes. In spite of these difficulties, the majority of NTM lung disease patients are still treated successfully. Because the prevalence of NTM is rising, it is increasingly necessary for clinicians to understand those unique aspects of NTM lung disease diagnosis and treatment that differ from tuberculosis and that contribute to limited treatment options.
引用
收藏
页码:135 / 142
页数:8
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