Nontuberculous mycobacterial (NTM) lung diseases present formidable obstacles to successful management, especially when compared with tuberculosis, beginning with diagnosis and extending through treatment. Factors peculiar to NTM disease such as extensive microbial resistance mechanisms and difficult to interpret, even misleading, in vitro drug susceptibility patterns are just two of the multiple and frustrating clinical management challenges. More conventional problems such as drug-drug interactions, medication side-effects, and nonadherence with therapy add further impediments to successful outcomes. In spite of these difficulties, the majority of NTM lung disease patients are still treated successfully. Because the prevalence of NTM is rising, it is increasingly necessary for clinicians to understand those unique aspects of NTM lung disease diagnosis and treatment that differ from tuberculosis and that contribute to limited treatment options.
机构:Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Basaraba, Randall J.
;
DeGroote, Mary Ann
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机构:Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
DeGroote, Mary Ann
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Ordway, Diane J.
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Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Lab, Ft Collins, CO 80523 USAUniv Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Ordway, Diane J.
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Rubinsztein, David C.
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Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 0XY, EnglandUniv Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Rubinsztein, David C.
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Floto, R. Andres
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Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Papworth Hosp, Adult Cyst Fibrosis Ctr, Cambridge CB3 8RE, EnglandUniv Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
机构:Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Basaraba, Randall J.
;
DeGroote, Mary Ann
论文数: 0引用数: 0
h-index: 0
机构:Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
DeGroote, Mary Ann
;
Ordway, Diane J.
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h-index: 0
机构:
Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Lab, Ft Collins, CO 80523 USAUniv Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Ordway, Diane J.
;
Rubinsztein, David C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 0XY, EnglandUniv Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Rubinsztein, David C.
;
Floto, R. Andres
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England
Papworth Hosp, Adult Cyst Fibrosis Ctr, Cambridge CB3 8RE, EnglandUniv Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England