Oncoepigenomics: Making histone lysine methylation count

被引：14

作者：

DeCarlo, Daniel ^{[1
]}

Hadden, M. Kyle ^{[1
]}

机构：

[1] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT 06269 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 56卷

关键词：

Histone lysine methyltransferases; Demethylases; Epigenetics; Enzyme inhibitors; Cancer; S-ADENOSYLHOMOCYSTEINE-HYDROLASE; MECHANISM-BASED INACTIVATOR; ZESTE HOMOLOG 2; METHYLTRANSFERASE G9A; DEMETHYLASE; SELECTIVE INHIBITORS; STRUCTURAL BASIS; CANCER INVASION; LEUKEMIA-CELLS; P53; FUNCTION;

D O I：

10.1016/j.ejmech.2012.08.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Increasing studies show that methylation of histone lysine residues is implicated in the development and progression of varying disease states such as schizophrenia, diabetes, and multiple human cancers. Targeting the specific enzymes responsible for these processes has fueled global investigation into the understanding and correction of epigenetic pathology. This review aims to assemble a timely account of the current progress against chromatin-modifying histone lysine methyltransferases (KMTs) and demethylases (KDMs) to inform ongoing and future efforts into this promising field. In particular, we report on their role in tumor growth and progression and the development of small molecules that modulate these enzymes. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：179 / 194

页数：16

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