The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival

被引：99

作者：

Wang, Xiao ^{[2
]}

Asplund, A. Charlotta ^{[3
]}

Porwit, Anna ^{[4
,5
]}

Flygare, Jenny ^{[2
]}

Smith, C. I. Edvard ^{[3
]}

Christensson, Birger ^{[2
]}

Sander, Birgitta ^{[1
,2
]}

机构：

[1] Karolinska Univ, Huddinge Hosp, Dept Pathol, SE-14186 Stockholm, Sweden

[2] Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden

[3] Karolinska Inst, Clin Res Ctr, Dept Lab Med, Stockholm, Sweden

[4] Karolinska Inst, Div Pathol, Dept Pathol & Oncol, Stockholm, Sweden

[5] Karolinska Univ, Hosp Solna, Stockholm, Sweden

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 143卷 / 02期

基金：

瑞典研究理事会;

关键词：

mantle cell lymphoma; sox11; nuclear expression; survival; proliferation;

D O I：

10.1111/j.1365-2141.2008.07329.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.

引用

页码：248 / 252

页数：5

共 12 条

[1] The establishment of neuronal properties is controlled by Sox4 and Sox11 [J].

Bergsland, Maria ;

Werme, Martin ;

Malewicz, Michal ;

Perlmann, Thomas ;

Muhr, Jonas .

GENES & DEVELOPMENT, 2006, 20 (24) :3475-3486

[2] Nuclear expression of the non-B-cell lineage Sox 11 transcription factor identifies mantle cell lymphoma [J].

Ek, Sara ;

Dictor, Michael ;

Jerkeman, Mats ;

Jirstrom, Karin ;

Borrebaeck, Carl A. K. .

BLOOD, 2008, 111 (02) :800-805

[3] Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma [J].

Flygare, J ;

Gustafsson, K ;

Kimby, E ;

Christensson, B ;

Sander, B .

FEBS LETTERS, 2005, 579 (30) :6885-6889

[4] Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma [J].

Gustafsson, Kristin ;

Christensson, Birger ;

Sander, Birgitta ;

Flygare, Jenny .

MOLECULAR PHARMACOLOGY, 2006, 70 (05) :1612-1620

[5] Internalization and recycling of the CB1 cannabinoid receptor [J].

Hsieh, C ;

Brown, S ;

Derleth, C ;

Mackie, K .

JOURNAL OF NEUROCHEMISTRY, 1999, 73 (02) :493-501

[6] High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma [J].

Islam, TC ;

Asplund, AC ;

Lindvall, JM ;

Nygren, L ;

Liden, J ;

Kimby, E ;

Christensson, B ;

Smith, CIE ;

Sander, B .

LEUKEMIA, 2003, 17 (09) :1880-1890

[7] SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth [J].

Jankowski, M. P. ;

Cornuet, P. K. ;

McILwrath, S. ;

Koerber, H. R. ;

Albers, K. M. .

NEUROSCIENCE, 2006, 143 (02) :501-514

[8] THE HUMAN SOX11 GENE - CLONING, CHROMOSOMAL ASSIGNMENT AND TISSUE EXPRESSION [J].

JAY, P ;

GOZE, C ;

MARSOLLIER, C ;

TAVIAUX, S ;

HARDELIN, JP ;

KOOPMAN, P ;

BERTA, P .

GENOMICS, 1995, 29 (02) :541-545

[9] Differential expression of SOX4 and SOX11 in medulloblastoma [J].

Lee, CJ ;

Appleby, VJ ;

Orme, AT ;

Chan, WI ;

Scotting, PJ .

JOURNAL OF NEURO-ONCOLOGY, 2002, 57 (03) :201-214

[10] Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors [J].

Lefebvre, Veronique ;

Dumitriu, Bogdan ;

Penzo-Mendez, Alfredo ;

Han, Yu ;

Pallavi, Bhattararn .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (12) :2195-2214

← 1 2 →