4-sulfonamidoanilide tertiary carbinols: A novel series of potassium channel openers

被引：10

作者：

Empfield, JR ^{[1
]}

Mayhugh, D ^{[1
]}

Ohnmacht, CJ ^{[1
]}

Frank, CA ^{[1
]}

Grant, T ^{[1
]}

Li, J ^{[1
]}

机构：

[1] ZENECA PHARMACEUT, DEPT PHARMACOL, WILMINGTON, DE 19897 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00111-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sulfonamides are viable replacements for the phenylsulfonyl acid benzoyl moieties initially described for the anilide tertiary carbinol series of K-ATP potassium channel openers. The SAR of this new series and the synthetic chemistry employed to generate its members are described. (C) 1997 Elsevier Science Ltd.

引用

页码：775 / 778

页数：4

共 15 条

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