Three-Dimensional Identification of the Medial Longitudinal Fasciculus in the Human Brain: A Diffusion Tensor Imaging Study

被引:3
作者
Yeo, Sang Seok [1 ]
Jang, Sung Ho [2 ]
Kwon, Jung Won [1 ]
Cho, In Hee [1 ]
机构
[1] Dankook Univ, Dept Phys Therapy, Coll Hlth Sci, Cheonan 31116, South Korea
[2] Yeungnam Univ, Dept Phys Med & Rehabil, Coll Med, Daegu 42415, South Korea
基金
新加坡国家研究基金会;
关键词
medial longitudinal fasciculus; visual vertical; diffusion tensor imaging; probabilistic diffusion tensor imaging tractography; MULTIPLE-SCLEROSIS; INTERNUCLEAR OPHTHALMOPLEGIA; STEM; PATHWAYS; MIDBRAIN;
D O I
10.3390/jcm9051340
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The medial longitudinal fasciculus (MLF) interacts with eye movement control circuits involved in the adjustment of horizontal, vertical, and torsional eye movements. In this study, we attempted to identify and investigate the anatomical characteristics of the MLF in human brain, using probabilistic diffusion tensor imaging (DTI) tractography. Methods: We recruited 31 normal healthy adults and used a 1.5-T scanner for DTI. To reconstruct MLFs, a seed region of interest (ROI) was placed on the interstitial nucleus of Cajal at the midbrain level. A target ROI was located on the MLF of the medulla in the reticular formation of the medulla. Mean values of fractional anisotropy, mean diffusivity, and tract volumes of MLFs were measured. Results: The component of the MLF originated from the midbrain MLF, descended through the posterior side of the medial lemniscus (ML) and terminated on the MLF of medulla on the posterior side of the ML in the medulla midline. DTI parameters of right and left MLFs were not significantly different. Conclusion: The tract of the MLF in healthy brain was identified by probabilistic DTI tractography. We believe this study will provide basic data and aid future comparative research on lesion or age-induced MLF changes.
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页数:9
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