Characterization of a Novel Population of Low-Density Granulocytes Associated with Disease Severity in HIV-1 Infection

被引：94

作者：

Cloke, Thomas ^{[1
]}

Munder, Markus ^{[2
]}

Taylor, Graham ^{[3
]}

Mueller, Ingrid ^{[1
]}

Kropf, Pascale ^{[4
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Immunol Sect, Dept Med, London, England

[2] Univ Med Ctr Mainz, Dept Med Hematol Oncol & Pneumol 3, Mainz, Germany

[3] Univ London Imperial Coll Sci Technol & Med, Dept Med, Infect Dis Sect, London, England

[4] London Sch Hyg & Trop Med, Immunol & Infect Dept, London WC1, England

来源：

PLOS ONE | 2012年 / 7卷 / 11期

基金：

英国惠康基金;

关键词：

SUPPRESSOR-CELLS; ENDOTHELIAL-CELLS; ARGINASE-I; NEUTROPHIL; ADHERENCE; CD18;

D O I：

10.1371/journal.pone.0048939

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mechanisms resulting in progressive immune dysfunction during the chronic phase of HIV infection are not fully understood. We have previously shown that arginase, an enzyme with potent immunosuppressive properties, is increased in HIV seropositive (HIV+) patients with low CD4(+) T cell counts. Here we show that the cells expressing arginase in peripheral blood mononuclear cells of HIV+ patients are low-density granulocytes (LDGs) and that whereas these cells have a similar morphology to normal-density granulocyte, they are phenotypically different. Importantly, our results reveal that increased frequencies of LDGs correlate with disease severity in HIV+ patients.

引用

页数：7

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