The trithorax-group and Polycomb-group chromatin modifiers: implications for disease

被引：71
作者：
van Lohuizen, M [1 ]
机构：
[1] Netherlands Canc Inst, Dept Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 03期
关键词：
D O I：
10.1016/S0959-437X(99)80053-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The chromatin structure associated transcriptional memory function by Polycomb-group and trithorax-group protein complexes integrate normal development with control of cellular proliferation. This is illustrated by recent mechanistic insights that link Polycomb repression with histone deacetylases and the identification of new target genes that provide a connection to cell cycle control and tumorigenesis.
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收藏
页码：355 / 361
页数：7
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