Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

被引：77

作者：

Azab, Mohammad Emad ^{[1
]}

Youssef, Mohamed M. ^{[2
]}

El-Bordany, Eman A. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Organ Synthet Lab, Cairo 11566, Egypt

[2] Taif Univ, Fac Sci, Dept Chem, At Taif 21974, Saudi Arabia

来源：

MOLECULES | 2013年 / 18卷 / 01期

关键词：

cyanoacetylhydrazide; sulfonamide; pyridazines; pyrazoles; oxazole; pyrimidines; antibacterial activity; MICROWAVE-ASSISTED SYNTHESIS; ANALGESIC ACTIVITY; DERIVATIVES; INHIBITORS; SULFAMIDE; UTILITY; PYRIMIDINE; THIOPHENE;

D O I：

10.3390/molecules18010832

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active methylene compounds producing pyran, pyridine and pyridazine derivatives. Also, the reactivity of the precursor hydrazone towards hydrazine derivatives to give pyrazole and oxazole derivatives was studied. On the other hand, treatment of the same precursor with urea, thiourea and/or guanidine hydrochloride furnished pyrimidine and thiazine derivatives, respectively. The newly synthesized compounds were tested for antibacterial activity, whereby eight compounds were found to have high activities.

引用

页码：832 / 844

页数：13

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