Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi

被引：32

作者：

Sashidhara, Koneni V. ^{[1
]}

Singh, Suriya P. ^{[1
]}

Misra, Sweta ^{[2
]}

Gupta, Jyoti ^{[2
]}

Misra-Bhattacharya, Shailja ^{[2
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] CSIR Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 50卷

关键词：

Bauhinia racemosa; Galactolipids; Antifilarial; Brugia malayi; Jird; IN-VITRO; PLANTS; PROGRAM;

D O I：

10.1016/j.ejmech.2012.01.057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay guided fractionation of ethanolic extract of the leaves of Bauhinia racemosa led to the isolation of galactolipid and catechin class of the compounds (1-7) from the most active n-butanol fraction (F4). Among the active galactolipids, 1 emerged as the lead molecule which was active on both forms of lymphatic filarial parasite, Brugia malayi. It was found to be better than the standard drug ivermectin and diethylcarbamazine (DEC) in terms of dose and efficacy. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：230 / 235

页数：6

共 38 条

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