Will anti-amyloid therapies work for Alzheimer's disease?

被引:58
作者
St George-Hyslop, Peter H. [1 ,2 ,3 ]
Morris, John C. [4 ]
机构
[1] Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0XY, England
[2] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
[3] Univ Toronto, Toronto Western Hosp, Div Neurol, Dept Med, Toronto, ON M5T 2S8, Canada
[4] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
基金
英国惠康基金;
关键词
D O I
10.1016/S0140-6736(08)61047-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:180 / 182
页数:3
相关论文
共 14 条
  • [1] Neuronal damage in brain inflammation
    Aktas, Orhan
    Ullrich, Oliver
    Infante-Duarte, Carmen
    Nitsch, Robert
    Zipp, Frauke
    [J]. ARCHIVES OF NEUROLOGY, 2007, 64 (02) : 185 - 189
  • [2] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN
    GLENNER, GG
    WONG, CW
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) : 885 - 890
  • [3] Long-term effects of Aβ42 immunisation in Alzheimer's disease:: follow-up of a randomised, placebo-controlled phase I trial
    Holmes, Clive
    Boche, Delphine
    Wilkinson, David
    Yadegarfar, Ghasem
    Hopkins, Vivienne
    Bayer, Anthony
    Jones, Roy W.
    Bullock, Roger
    Love, Seth
    Neal, James W.
    Zotova, Elina
    Nicoll, James A. R.
    [J]. LANCET, 2008, 372 (9634) : 216 - 223
  • [4] Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    Janus, C
    Pearson, J
    McLaurin, J
    Mathews, PM
    Jiang, Y
    Schmidt, SD
    Chishti, MA
    Horne, P
    Heslin, D
    French, J
    Mount, HTJ
    Nixon, RA
    Mercken, M
    Bergeron, C
    Fraser, PE
    St George-Hyslop, P
    Westaway, D
    [J]. NATURE, 2000, 408 (6815) : 979 - 982
  • [5] Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
    Lewis, J
    Dickson, DW
    Lin, WL
    Chisholm, L
    Corral, A
    Jones, G
    Yen, SH
    Sahara, N
    Skipper, L
    Yager, D
    Eckman, C
    Hardy, J
    Hutton, M
    McGowan, E
    [J]. SCIENCE, 2001, 293 (5534) : 1487 - 1491
  • [6] Aβ-42 deposition precedes other changes in PS-1 Alzheimer's disease
    Lippa, CF
    Nee, LE
    Mori, H
    St George-Hyslop, P
    [J]. LANCET, 1998, 352 (9134) : 1117 - 1118
  • [7] Price JL, 1999, ANN NEUROL, V45, P358, DOI 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO
  • [8] 2-X
  • [9] Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
    Roberson, Erik D.
    Scearce-Levie, Kimberly
    Palop, Jorge J.
    Yan, Fengrong
    Cheng, Irene H.
    Wu, Tiffany
    Gerstein, Hilary
    Yu, Gui-Qiu
    Mucke, Lennart
    [J]. SCIENCE, 2007, 316 (5825) : 750 - 754
  • [10] Rogaeva E, 2006, J ALZHEIMERS DIS, V9, P381