Thrombin generation: What have we learned?

被引：138

作者：

Al Dieri, Raed ^{[1
]}

de Laat, Bas ^{[1
]}

Hemker, H. Coenraad ^{[1
]}

机构：

[1] Maastricht Univ, Synapse BV, CARIM Sch Cardiovasc Dis, NL-6229 EV Maastricht, Netherlands

来源：

BLOOD REVIEWS | 2012年 / 26卷 / 05期

关键词：

Thrombin generation; Thrombosis; Bleeding; Anticoagulation; Clotting system; PLATELET-RICH PLASMA; ACTIVATED PROTEIN-C; SEVERE HEMOPHILIA-A; ACUTE MYOCARDIAL-INFARCTION; RECOMBINANT FACTOR VIIA; FACTOR PATHWAY INHIBITOR; TISSUE FACTOR PATHWAY; DEEP-VEIN THROMBOSIS; FACTOR XA INHIBITOR; VENOUS THROMBOSIS;

D O I：

10.1016/j.blre.2012.06.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombin is a pivotal player in the coagulation system. In clotting blood a transient wave of thrombin appears after a lag time. Clotting occurs at the start of the wave. The amount of thrombin formed reflects the function of the hemostatic system much better than the clotting time does: The more thrombin the less bleeding but the more thrombosis, the less thrombin the more bleeding but the less thrombosis" has been shown to hold for congenital and acquired tendencies to venous thrombosis and bleeding and under all variants of antithrombotic treatment. The situation with arterial thrombosis is less clear. Calibrated automated thrombinography (CAT) allows quantitative assessment of the thrombin generation (TG) curve in platelet poor as well as in platelet rich plasma. Procedures to measure TG in whole blood and at the point of care are under development. TG measurement in platelet rich plasma underlines the close cooperation between platelets and the clotting system and challenges the traditional division between primary and secondary hemostases. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：197 / 203

页数：7

共 123 条

[1] The ionic contrast medium ioxaglate interferes with thrombin-mediated feedback activation of factor V, factor VIII and platelets [J].