Regulating mammalian transcription with RNA

被引：21

作者：

Corey, DR ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 12期

关键词：

D O I：

10.1016/j.tibs.2005.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.

引用

页码：655 / 658

页数：4

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