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Mitochondrial Functionality and Chemical Compound Action on Sperm Function
被引:19
作者:
Amaral, S.
[1
,3
]
Tavares, R. S.
[1
]
Baptista, M.
[1
,3
]
Sousa, M. I.
[1
]
Silva, A.
[1
]
Escada-Rebelo, S.
[1
]
Paiva, C. P.
[1
]
Ramalho-Santos, J.
[1
,2
]
机构:
[1] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Biol Reprod & Stem Cell Grp, P-3004517 Coimbra, Portugal
[2] Univ Coimbra, Dept Life Sci, P-3001401 Coimbra, Portugal
[3] Univ Coimbra, Inst Interdisciplinary Res, P-3004517 Coimbra, Portugal
关键词:
Mitochondria;
sperm;
male fertility;
lifestyle-associated compounds;
male contraceptives;
sensor;
POLYUNSATURATED FATTY-ACIDS;
URINARY PHTHALATE METABOLITES;
SIGNAL-TRANSDUCTION PATHWAYS;
COCAINE-INDUCED APOPTOSIS;
IN-VITRO FERTILIZATION;
HUMAN FOLLICULAR-FLUID;
GREEN TEA POLYPHENOL;
FROZEN-THAWED SEMEN;
DIETARY FISH-OIL;
SEMINAL PLASMA;
D O I:
10.2174/0929867323666160425113518
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
During the last decade, several studies have shown that mitochondrial parameters, such as integrity, respiratory activity, membrane potential and ROS production are intimately linked with sperm quality. Given the limitations of conventional semen analyses in terms of predicting male fertility, an increasing number of studies are focusing on the characterization of sperm mitochondria in order to more accurately assess sperm functionality. Moreover, mitochondria from several organs, such as the liver, have been described as a powerful screening tool for drug safety, being an easy in vitro model to assess the toxicity of distinct families of compounds. Given that mitochondrial functionality is intimately related to sperm homeostasis, it has become important to understand how compounds, ranging from dietary supplements, environmental pollutants, dependency-inducing drugs to pharmacological agents (such as erectile dysfunction-targeted drugs and male contraceptives) affect sperm mitochondrial function. In this review, we discuss studies describing the effects of various chemical agents on spermatozoa, with particular emphasis on mitochondrial function. From the extensive literature analyzed, we conclude that in some cases the role of sperm mitochondria as putative predictors of sperm functionality is very obvious, while in others further studies are needed to clarify this issue.
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页码:3575 / 3606
页数:32
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