The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX)

被引：35
|
作者：
Giverhaug, T [1 ]
Loennechen, T
Aarbakke, J
机构：
[1] Univ Tromso, Inst Pharm, Dept Pharmacol, N-9037 Tromso, Norway
[2] Univ Tromso, Inst Med Biol, N-9037 Tromso, Norway
来源：
GENERAL PHARMACOLOGY | 1999年 / 33卷 / 04期
关键词：
6-mercaptopurine; methotrexate; interaction;
D O I：
10.1016/S0306-3623(99)00022-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antimetabolites 6-mercaptopurine (6-MP) and metliotrexate (MTX) are the cornerstones in the maintenance treatment of children's acute lymphoblastic leukemia (ALL). The biochemical mechanisms underlying the increased therapeutic efficacy of the combination of these drugs have not yet been elucidated. However, both drugs interact with important pathways, such as purine de novo synthesis (PDNS), purine salvage, and methylation reactions. A review of the mechanistic aspects of the interactions between 6-MP and MTX is given. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：341 / 346
页数：6
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