In vitro assessment of deferoxamine on mesenchymal stromal cells from tumor and bone marrow

被引：13

作者：

Wang, Guoping

Shen, Guobo

Yin, Tao ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Peoples South Rd Three Sect 17, Chengdu 610041, Peoples R China

[2] Collaborat Innovat Ctr Biotherapy, Peoples South Rd Three Sect 17, Chengdu 610041, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2017年 / 49卷

基金：

中国国家自然科学基金;

关键词：

Deferoxamine; Mesenchymal stromal cells; ICAM-1; VCAM-1; IRON CHELATION; STEM-CELLS; DESFERRIOXAMINE; ICAM-1; APOPTOSIS; TOXICITY; SURVIVAL; PHARMACOKINETICS; FERRIOXAMINE; PROTECTS;

D O I：

10.1016/j.etap.2016.11.014

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Deferoxamine (DFO), an iron chelator, is commonly used to remove excess iron from the body. DFO has also been demonstrated to have anti-tumor effect. However, there is no available report on the effect of deferoxamine on mesenchymal stromal cells (MSCs). In this study, we first isolated tumor-associated MSCs (TAMSCs) from EG-7 tumors, which were positive for CD29, CD44, CD73, CD90 and CD105. Ex vivo cultured stem cells derived from tumor and bone marrow compartment were exposed to DFO. We demonstrated that DFO had growth-arresting and apoptosis-inducing effect on TAMSCs and bone marrow MSCs (BMMSCs). DFO also influenced the expression pattern of adhesion molecule VCAM-1 on both TAMSCs and BMMSCs. Notwithstanding its widespread use, our results here warrants caution in the application of DFO, and also highlights the need for careful evaluation of the bone marrow compartment in patients receiving DFO treatment. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：58 / 64

页数：7

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