The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition ofTLR4/NF-kappaBpathway

被引：71

作者：

Dejban, Pegah ^{[1
,2
,3
]}

Nikravangolsefid, Nasrin ^{[4
]}

Chamanara, Mohsen ^{[5
]}

Dehpour, Ahmadreza ^{[1
,2
]}

Rashidian, Amir ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[2] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran

[3] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA

[4] Iran Univ Med Sci, Fac Med, Tehran, Iran

[5] AJA Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

来源：

PHYTOTHERAPY RESEARCH | 2021年 / 35卷 / 02期

关键词：

inflammatory bowel diseases (IBD); natural products; TLR4; NF-kappaB signaling pathway; TNBS-INDUCED COLITIS; HUMAN HEPATOMA-CELLS; TOLL-LIKE RECEPTORS; KAPPA-B; ULCERATIVE-COLITIS; ALTERNATIVE MEDICINE; GUT MICROBIOTA; IN-VIVO; PONCIRIN; TLR4;

D O I：

10.1002/ptr.6866

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inflammatory bowel disease (IBD) is a lifelong and recurrent disease of the gastrointestinal tract that afflicts many people in the world. Growing evidence has currently indicated that dysfunction of immune system, particularly toll-like receptors 4 (TLR4) signaling pathway dysfunction plays a pivotal part in the pathogenesis of IBD. TLR4 signaling is involved both in the pathogenesis and in the efficacy of treatment of IBD. There are some medicinal products and herbal medicines, which their role in the treatment of IBD through modulation of TLR4 signaling has been implicated. The purpose of this review article is to summarize those medicinal products and herbal medicines.

引用

页码：835 / 845

页数：11

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