MicroRNA-mediated incoherent feedforward motifs are robust

被引：0

作者：

Xu, Feng-dan ^{[1
]}

Liu, Zeng-rong ^{[1
]}

Shen, Jian-wei ^{[1
]}

机构：

[1] Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China

来源：

OPTIMIZATION AND SYSTEMS BIOLOGY, PROCEEDINGS | 2008年 / 9卷

关键词：

MicroRNA; incoherent; motif; robust;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this paper, we integrate transcriptional and-posttranscriptional regulation into microRNA-mediated incoherent feedforward motifs and analyze their dynamical behaviors and functions. The analysis show that the behaviors of the system are almost uninfluenced by the varying input in certain ranges and the introducing of delay and noise. The results indicate that microRNA-mediated incoherent feedforward motifs greatly enhance the robustness of gene regulation.

引用

页码：62 / 67

页数：6

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