Effects of Tirofiban combined with Betaloc on serum P-selectin, BNP levels, and cardiac function in patients with acute myocardial infarction after PCI

Objective: To investigate the effects of tirofiban combined with betaloc on serum P-selectin, brain natriuretic peptide (BNP) levels, and cardiac function in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods: Ninety-five patients were randomly divided into the observation group and the control group. The control group was treated with betaloc alone, while the observation group was treated with tirofiban and betaloc. Patient serum P-selectin and BNP levels, hemodynamic parameters, cardiac function indexes, troponin T (TNT), and C-reactive protein levels were observed and compared. Results: The total effective rate of the observation group was significantly higher than that of the control group (P=0.015). Parameters were significantly lower in both groups after treatment, and there was significant difference between the two groups (both P=0.000). P-selectin and BNP levels in both groups significantly decreased after treatment, and there was significant difference between the two groups (both P=0.000). LVEF was significantly increased in both groups, with significant difference between the two groups (P=0.000). The LVEDD and LVESD of the observation group were significantly lower than those of the control group after treatment (both P=0.000). Both TNT and hs-CRP were significantly reduced and with significant differences between the two groups (all P=0.000). Conclusion: Treatment with tirofiban combined with betaloc after PCI in patients with AMI can improve clinical outcomes and has a high clinical value owing to its ability to reduce P-selectin and BNP levels and to improve cardiac function and hemodynamic status.